LncSUMO1P3 exacerbates malignant behaviors of esophageal squamous cell carcinoma cells via miR-486-5p/PHF8/CD151

BackgroundEsophageal squamous cell carcinoma (ESCC) is a malignancy usually associated with smoking or alcohol consumption. The involvement of long noncoding RNAs (lncRNAs) in the regulation tumor development and metastasis through molecular mechanisms has been unveiled by accumulating evidence. However, function lncRNA SUMO1 Pseudogene 3 (lncSUMO1P3) essential to ESCC remains obscure.MethodsReverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) Western blot (WB) analysis were done measure RNA protein levels. Functional assays carried out examine changes phenotype. Supported bioinformatics analysis, mechanism for assessment putative interactions among different genes.ResultsLlncSUMO1P3 was aberrantly up-regulated lines, lncSUMO1P3 deficiency could hamper proliferation, migration invasion as well epithelial-mesenchymaltransition (EMT) while overexpression led opposite consequences. LncSUMO1P3 competitively bind microRNA-486-5p (miR-486-5p) PHD finger 8 (PHF8) modulate CD151 expression. also verified regulate biological behaviors.ConclusionOur study revealed that lncSUMO1P3, cells, sponge miR-486-5p recruit PHF8 up-regulate CD151, thus influencing malignant behaviors cells.